|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Muscarinic acetylcholine receptor M3, CHRM3|
|Target/Specificity||Human CHRM3 / M3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CHRM3 / M3 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Peralta E.G.,et al.EMBO J. 6:3923-3929(1987).
Bonner T.I.,et al.Neuron 1:403-410(1988).
Kitano T.,et al.Mol. Biol. Evol. 21:936-944(2004).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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