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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ESRRA / ERR Alpha Antibody (Internal)   

ESRRA / ERR Alpha Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - ESRRA / ERR Alpha Antibody (Internal) ALS10823
    Anti-ESRRA antibody ALS10823 IHC of human breast carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P11474
Reactivity Human, Mouse, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 46kDa
Dilution IHC-P (8-24 µg/ml)
Additional Information
Gene ID 2101
Other Names Steroid hormone receptor ERR1, Estrogen receptor-like 1, Estrogen-related receptor alpha, ERR-alpha, Nuclear receptor subfamily 3 group B member 1, ESRRA, ERR1, ESRL1, NR3B1
Target/Specificity Human ESRRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsESRRA / ERR Alpha Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESRRA
Synonyms ERR1, ESRL1, NR3B1
Function Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:18063693}
Volume 50 µl
Research Areas
Citations (0)

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Background

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

References

Giguere V.,et al.Nature 331:91-94(1988).
Yang N.,et al.J. Biol. Chem. 271:5795-5804(1996).
Taylor T.D.,et al.Nature 440:497-500(2006).
Wiley S.R.,et al.Genes Dev. 7:2206-2219(1993).
Sladek R.,et al.Mol. Cell. Biol. 17:5400-5409(1997).

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$ 395.00
Cat# ALS10823
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