|Application ||WB, IHC-P|
|Dilution||IHC-P (7-16 µg/ml)|
|Other Names||Prokineticin receptor 1, PK-R1, G-protein coupled receptor 73, G-protein coupled receptor ZAQ, GPR73a, PROKR1, GPR73, PKR1|
|Target/Specificity||Human PROKR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||PROKR1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.|
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Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
Masuda Y.,et al.Biochem. Biophys. Res. Commun. 293:396-402(2002).
Soga T.,et al.Biochim. Biophys. Acta 1579:173-179(2002).
Lin D.C.-H.,et al.J. Biol. Chem. 277:19276-19280(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
Martin A.L.,et al.Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
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