|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Bovine|
|Dilution||IHC-P (10-15 µg/ml)|
|Other Names||Brain-specific angiogenesis inhibitor 1, BAI1|
|Target/Specificity||Human BAI1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||ADGRB1 / BAI1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Likely to be concentrated at cell-cell adhesion sites|
|Tissue Location||Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
Nishimori H.,et al.Oncogene 15:2145-2150(1997).
Nusbaum C.,et al.Nature 439:331-335(2006).
Shiratsuchi T.,et al.Biochem. Biophys. Res. Commun. 247:597-604(1998).
Oda K.,et al.Cytogenet. Cell Genet. 84:75-82(1999).
Wu Y.,et al.J. Biol. Chem. 275:21477-21485(2000).
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