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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MKP-8 / DUSP26 Antibody (C-Terminus)   

MKP-8 / DUSP26 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - MKP-8 / DUSP26 Antibody (C-Terminus) ALS10874
    Anti-MKP-8 / DUSP26 antibody IHC of human Lung, Small Cell Carcinoma.
  • IHC - MKP-8 / DUSP26 Antibody (C-Terminus) ALS10874
    Anti-MKP-8 / DUSP26 antibody IHC of human Breast, Carcinoma.
  • IHC - MKP-8 / DUSP26 Antibody (C-Terminus) ALS10874
    Anti-MKP-8 / DUSP26 antibody IHC of human Pancreas, Carcinoma.
  • IHC - MKP-8 / DUSP26 Antibody (C-Terminus) ALS10874
    Anti-MKP-8 / DUSP26 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9BV47
Reactivity Human, Rabbit, Hamster, Monkey, Pig, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 78986
Other Names Dual specificity protein phosphatase 26, 3.1.3.16, 3.1.3.48, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, DUSP26, DUSP24, LDP4, MKP8, NATA1, SKRP3
Target/Specificity Human DUSP26. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsMKP-8 / DUSP26 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP26
Synonyms DUSP24, LDP4, MKP8, NATA1, SKRP3
Function Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
Cellular Location Cytoplasm. Nucleus. Golgi apparatus.
Tissue Location Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
Volume 50 µl
Research Areas
Citations (0)

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Background

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

References

Vasudevan S.A.,et al.Biochem. Biophys. Res. Commun. 330:511-518(2005).
Yu W.,et al.Oncogene 26:1178-1187(2007).
Takagaki K.,et al.Mol. Cell. Biochem. 296:177-184(2007).
Zama T.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS10874
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