PTPRA / RPTP-Alpha Antibody (Extracellular Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P18433 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 91kDa |
Dilution | IHC-P (15 µg/ml) |
Gene ID | 5786 |
---|---|
Other Names | Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha, 3.1.3.48, PTPRA, PTPA, PTPRL2 |
Target/Specificity | Human PTPRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except HLA-S (59%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | PTPRA / RPTP-Alpha Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTPRA |
---|---|
Synonyms | PTPA, PTPRL2 |
Function | Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18052}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250|UniProtKB:P18052} |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
References
Sap J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:6112-6116(1990).
Kaplan R.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990).
Krueger N.X.,et al.EMBO J. 9:3241-3252(1990).
Ohagi S.,et al.Nucleic Acids Res. 18:7159-7159(1990).
Jirik F.R.,et al.FEBS Lett. 273:239-242(1990).
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