|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Horse, Bovine|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Dual specificity protein phosphatase 23, 188.8.131.52, 184.108.40.206, Low molecular mass dual specificity phosphatase 3, LDP-3, VH1-like phosphatase Z, DUSP23, LDP3, VHZ|
|Target/Specificity||Human DUSP23. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||DUSP23 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear|
|Tissue Location||Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach|
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Takagaki K.,et al.Biochem. J. 383:447-455(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Alonso A.,et al.J. Biol. Chem. 279:35768-35774(2004).
Wu Q.,et al.Int. J. Biochem. Cell Biol. 36:1542-1553(2004).
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