|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Horse, Bovine|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Dual specificity protein phosphatase 23, 220.127.116.11, 18.104.22.168, Low molecular mass dual specificity phosphatase 3, LDP-3, VH1-like phosphatase Z, DUSP23, LDP3, VHZ|
|Target/Specificity||Human DUSP23. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||DUSP23 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear|
|Tissue Location||Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Takagaki K.,et al.Biochem. J. 383:447-455(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Alonso A.,et al.J. Biol. Chem. 279:35768-35774(2004).
Wu Q.,et al.Int. J. Biochem. Cell Biol. 36:1542-1553(2004).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.