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GPR55 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - GPR55 Antibody (Extracellular Domain) ALS10881
    Anti-GPR55 antibody IHC of human Ovary, Carcinoma.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9Y2T6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Dilution IHC-P (5-10 µg/ml)
Additional Information
Gene ID 9290
Other Names G-protein coupled receptor 55, GPR55
Target/Specificity Human GPR55. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR55 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR55
Function G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. Higly expressed in macrophages and B-cells (PubMed:36523570, PubMed:37544935).
Research Areas
Citations (0)
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Background

May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

References

Sawzdargo M.,et al.Brain Res. Mol. Brain Res. 64:193-198(1999).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Oka S.,et al.Biochem. Biophys. Res. Commun. 362:928-934(2007).
Henstridge C.M.,et al.FASEB J. 23:183-193(2009).
Kapur A.,et al.J. Biol. Chem. 284:29817-29827(2009).

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$ 467.50
Cat# ALS10881
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