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TAOK1 / TAO1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q7L7X3 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Xenopus, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 116kDa |
| Dilution | IHC-P (4.4 µg/ml) |
| Gene ID | 57551 |
|---|---|
| Other Names | Serine/threonine-protein kinase TAO1, 2.7.11.1, Kinase from chicken homolog B, hKFC-B, MARK Kinase, MARKK, Prostate-derived sterile 20-like kinase 2, PSK-2, PSK2, Prostate-derived STE20-like kinase 2, Thousand and one amino acid protein kinase 1, TAOK1, hTAOK1, TAOK1, KIAA1361, MAP3K16, MARKK |
| Target/Specificity | Human TAOK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TAOK3 (63%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | TAOK1 / TAO1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TAOK1 |
|---|---|
| Synonyms | KIAA1361, MAP3K16, MARKK |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
References
Yustein J.T.,et al.Oncogene 22:6129-6141(2003).
Jenkins S.G.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Matsuda A.,et al.Patent number WO2004058805, 15-JUL-2004.
Nagase T.,et al.DNA Res. 7:65-73(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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