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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TAOK1 / TAO1 Antibody (Internal)   

TAOK1 / TAO1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - TAOK1 / TAO1 Antibody (Internal) ALS10882
    Anti-TAOK1 antibody ALS10882 IHC of human brain, hippocampus.
  • IHC - TAOK1 / TAO1 Antibody (Internal) ALS10882
    Anti-TAOK1 / TAO1 antibody IHC of human Lung, Non-Small Cell Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q7L7X3
Reactivity Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Xenopus, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 116kDa
Dilution IHC-P (4.4 µg/ml)
Additional Information
Gene ID 57551
Other Names Serine/threonine-protein kinase TAO1, 2.7.11.1, Kinase from chicken homolog B, hKFC-B, MARK Kinase, MARKK, Prostate-derived sterile 20-like kinase 2, PSK-2, PSK2, Prostate-derived STE20-like kinase 2, Thousand and one amino acid protein kinase 1, TAOK1, hTAOK1, TAOK1, KIAA1361, MAP3K16, MARKK
Target/Specificity Human TAOK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TAOK3 (63%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsTAOK1 / TAO1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAOK1
Synonyms KIAA1361, MAP3K16, MARKK
Function Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.
Volume 50 µl
Research Areas
Citations (0)

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Background

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.

References

Yustein J.T.,et al.Oncogene 22:6129-6141(2003).
Jenkins S.G.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Matsuda A.,et al.Patent number WO2004058805, 15-JUL-2004.
Nagase T.,et al.DNA Res. 7:65-73(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS10882
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