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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ACVR1C / ALK7 Antibody (Internal)   

ACVR1C / ALK7 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - ACVR1C / ALK7 Antibody (Internal) ALS10885
    Anti-ACVR1C antibody ALS10885 IHC of human spleen.
  • IHC - ACVR1C / ALK7 Antibody (Internal) ALS10885
    Anti-ACVR1C antibody ALS10885 IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8NER5
Reactivity Human, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 55kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 130399
Other Names Activin receptor type-1C, 2.7.11.30, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ACVR1C (HGNC:18123)
Target/Specificity Human ACVR1C. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsACVR1C / ALK7 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACVR1C (HGNC:18123)
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy
Volume 50 µl
Research Areas
Citations (0)

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Background

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

References

Bondestam J.,et al.Cytogenet. Cell Genet. 95:157-162(2001).
Roberts H.J.,et al.Biol. Reprod. 68:1719-1726(2003).
Hillier L.W.,et al.Nature 434:724-731(2005).
Xu G.,et al.J. Clin. Endocrinol. Metab. 89:5523-5534(2004).
Greenman C.,et al.Nature 446:153-158(2007).

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$ 395.00
Cat# ALS10885
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