|Dilution||IHC-P (1 µg/ml)|
|Other Names||Serine/threonine-protein kinase Nek7, 220.127.116.11, Never in mitosis A-related kinase 7, NimA-related protein kinase 7, NEK7|
|Target/Specificity||Human NEK7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NEK7 Antibody (Kinase Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody|
|Tissue Location||Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.
Kimura M.,et al.Cytogenet. Cell Genet. 94:33-38(2001).
Melton D.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Belham C.,et al.J. Biol. Chem. 278:34897-34909(2003).
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