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MST1R / RON Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - MST1R / RON Antibody (N-Terminus) ALS10891
    Anti-MST1R / RON antibody ALS10891 IHC of human colon, surface epithelium.
  • SPECIFICATION
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q04912
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 152kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 4486
Other Names Macrophage-stimulating protein receptor, MSP receptor, 2.7.10.1, CDw136, Protein-tyrosine kinase 8, p185-Ron, CD136, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, MST1R, PTK8, RON
Target/Specificity Human MST1R / RON. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsMST1R / RON Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MST1R
Synonyms PTK8, RON
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in colon, skin, lung and bone marrow.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

References

Ronsin C.,et al.Oncogene 8:1195-1202(1993).
Collesi C.,et al.Mol. Cell. Biol. 16:5518-5526(1996).
Jin P.,et al.Arthritis Res. Ther. 10:R73-R73(2008).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ponzetto C.,et al.Mol. Cell. Biol. 13:4600-4608(1993).

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$ 395.00
Cat# ALS10891
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