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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDK12 / CRKRS Antibody (Internal)   

CDK12 / CRKRS Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - CDK12 / CRKRS Antibody (Internal) ALS10901
    Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma.
  • IHC - CDK12 / CRKRS Antibody (Internal) ALS10901
    Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NYV4
Reactivity Human, Monkey, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 164kDa
Dilution IHC-P (6 µg/ml)
Additional Information
Gene ID 51755
Other Names Cyclin-dependent kinase 12, 2.7.11.22, 2.7.11.23, Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12, CDK12, CRK7, CRKRS, KIAA0904
Target/Specificity Human CDK12 / CRKRS. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AKAP12 (55%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCDK12 / CRKRS Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK12
Synonyms CRK7, CRKRS, KIAA0904
Function Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Cellular Location Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase
Tissue Location Ubiquitously expressed.
Volume 50 µl
Research Areas
Citations (0)

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Background

Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

References

Ko T.K.,et al.J. Cell Sci. 114:2591-2603(2001).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).

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$ 395.00
Cat# ALS10901
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