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MINK1 / MINK Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q8N4C8 |
| Reactivity | Human, Mouse, Monkey, Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 150kDa |
| Dilution | IHC-P (7 µg/ml) |
| Gene ID | 50488 |
|---|---|
| Other Names | Misshapen-like kinase 1, 2.7.11.1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6, MINK1 (HGNC:17565) |
| Target/Specificity | Human MINK1 / MAP4K6. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | MINK1 / MINK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MINK1 (HGNC:17565) |
|---|---|
| Function | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. |
| Cellular Location | Cytoplasm. Postsynaptic density. Cell projection, axon. Cell projection, dendrite |
| Tissue Location | Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
References
Dan I.,et al.FEBS Lett. 469:19-23(2000).
Hu Y.,et al.J. Biol. Chem. 279:54387-54397(2004).
Hu Y.,et al.J. Biol. Chem. 280:5128-5128(2005).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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