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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MINK1 / MINK Antibody (Internal)   

MINK1 / MINK Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - MINK1 / MINK Antibody (Internal) ALS10905
    Anti-MINK1 / MAP4K6 antibody ALS10905 IHC of human hippocampus.
  • IHC - MINK1 / MINK Antibody (Internal) ALS10905
    Anti-MINK1 / MAP4K6 antibody ALS10905 IHC of rat hippocampus.
  • IHC - MINK1 / MINK Antibody (Internal) ALS10905
    Anti-MINK1 / MINK antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8N4C8
Reactivity Human, Mouse, Monkey, Pig, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 150kDa
Dilution IHC-P (7 µg/ml)
Additional Information
Gene ID 50488
Other Names Misshapen-like kinase 1, 2.7.11.1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6, MINK1 (HGNC:17565)
Target/Specificity Human MINK1 / MAP4K6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsMINK1 / MINK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MINK1 (HGNC:17565)
Function Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Cellular Location Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite
Tissue Location Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis
Volume 50 µl
Research Areas
Citations (0)

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Background

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.

References

Dan I.,et al.FEBS Lett. 469:19-23(2000).
Hu Y.,et al.J. Biol. Chem. 279:54387-54397(2004).
Hu Y.,et al.J. Biol. Chem. 280:5128-5128(2005).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS10905
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