DHRS7 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q9Y394 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 38kDa |
Dilution | IHC-P (5-7.5 µg/ml) |
Gene ID | 51635 |
---|---|
Other Names | Dehydrogenase/reductase SDR family member 7, 1.1.-.-, Retinal short-chain dehydrogenase/reductase 4, retSDR4, DHRS7, DHRS7A, RETSDR4 |
Target/Specificity | Human DHRS7. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | DHRS7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DHRS7 (HGNC:21524) |
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Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28687384, PubMed:28457967). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28687384, PubMed:28457967). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta- dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046). |
Cellular Location | Endoplasmic reticulum membrane. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum (PubMed:24246760) However, it was later shown to be facing the cytosol (PubMed:28457967) |
Tissue Location | Found predominantly in the adrenal glands, liver, thyroid, prostate, small intestine, colon, stomach, kidney and brain (PubMed:26466768). Lower levels observed in skeletal muscle, the lung and the spleen (PubMed:26466768). |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
References
Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Haeseleer F.,et al.Methods Enzymol. 316:372-383(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
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