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DHRS7 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - DHRS7 Antibody (C-Terminus) ALS10953
    Anti-DHRS7 antibody ALS10953 IHC of human prostate.
    detail
  • IHC - DHRS7 Antibody (C-Terminus) ALS10953
    Anti-DHRS7 antibody ALS10953 IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9Y394
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Dilution IHC-P (5-7.5 µg/ml)
Additional Information
Gene ID 51635
Other Names Dehydrogenase/reductase SDR family member 7, 1.1.-.-, Retinal short-chain dehydrogenase/reductase 4, retSDR4, DHRS7, DHRS7A, RETSDR4
Target/Specificity Human DHRS7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsDHRS7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHRS7 (HGNC:21524)
Function NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28687384, PubMed:28457967). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28687384, PubMed:28457967). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta- dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046).
Cellular Location Endoplasmic reticulum membrane. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum (PubMed:24246760) However, it was later shown to be facing the cytosol (PubMed:28457967)
Tissue Location Found predominantly in the adrenal glands, liver, thyroid, prostate, small intestine, colon, stomach, kidney and brain (PubMed:26466768). Lower levels observed in skeletal muscle, the lung and the spleen (PubMed:26466768).
Volume 50 µl
Research Areas
Citations (0)
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References

Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Haeseleer F.,et al.Methods Enzymol. 316:372-383(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).

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$ 467.50
Cat# ALS10953
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