Renal Dipeptidase / DPEP1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P16444 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 1800 |
---|---|
Other Names | Dipeptidase 1, 3.4.13.19, Dehydropeptidase-I, Microsomal dipeptidase, Renal dipeptidase, hRDP, DPEP1, MDP, RDP |
Target/Specificity | Human DPEP1. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | Renal Dipeptidase / DPEP1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DPEP1 |
---|---|
Synonyms | MDP {ECO:0000303|PubMed:2303490}, RDP |
Function | Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408, PubMed:32325220). Hydrolyzes cystinyl- bis-glycine (cys-bis-gly) formed during glutathione degradation (PubMed:32325220). Possesses also beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem (PubMed:6334084, PubMed:32325220). |
Cellular Location | Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor. Note=Brush border membrane {ECO:0000250|UniProtKB:P31429} |
Tissue Location | Expressed in lung and kidneys. |
Volume | 50 µl |
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Background
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.
References
Satoh S.,et al.Biochim. Biophys. Acta 1172:181-183(1993).
Adachi H.,et al.J. Biol. Chem. 265:3992-3995(1990).
Satoh S.,et al.Biotechnol. Prog. 10:134-140(1994).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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