|Reactivity||Human, Mouse, Rabbit, Monkey, Horse, Xenopus, Bovine|
|Dilution||IHC-P (20 µg/ml)|
|Other Names||Dipeptidyl aminopeptidase-like protein 6, DPPX, Dipeptidyl aminopeptidase-related protein, Dipeptidyl peptidase 6, Dipeptidyl peptidase IV-like protein, Dipeptidyl peptidase VI, DPP VI, DPP6|
|Target/Specificity||Human DPP6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||DPP6 / Dipeptidylpeptidase 6 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed predominantly in brain.|
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Provided below are standard protocols that you may find useful for product applications.
May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2.
Yokotani N.,et al.Hum. Mol. Genet. 2:1037-1039(1993).
Hillier L.W.,et al.Nature 424:157-164(2003).
van Es M.A.,et al.Nat. Genet. 40:29-31(2008).
Garber K.,et al.Science 319:20-20(2008).
Alders M.,et al.Am. J. Hum. Genet. 84:468-476(2009).
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