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ATRN / Attractin Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O75882 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 159kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 8455 |
|---|---|
| Other Names | Attractin, DPPT-L, Mahogany homolog, ATRN, KIAA0548, MGCA |
| Target/Specificity | Human ATRN / Attractin. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | ATRN / Attractin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATRN |
|---|---|
| Synonyms | KIAA0548, MGCA |
| Function | Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted |
| Tissue Location | Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).
References
Tang W.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:6025-6030(2000).
Duke-Cohan J.S.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Duke-Cohan J.S.,et al.J. Biol. Chem. 270:14107-14114(1995).
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