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PIGR Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - PIGR Antibody (Extracellular Domain) ALS10980
    Anti-PIGR antibody ALS10980 IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P01833
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 83kDa
Dilution IHC-P (15-20 µg/ml)
Additional Information
Gene ID 5284
Other Names Polymeric immunoglobulin receptor, PIgR, Poly-Ig receptor, Hepatocellular carcinoma-associated protein TB6, Secretory component, PIGR
Target/Specificity Human PIGR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsPIGR Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIGR
Function [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Cellular Location [Polymeric immunoglobulin receptor]: Cell membrane; Single-pass type I membrane protein
Volume 100 µl
Research Areas
Citations (0)
citation

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Background

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

References

Krajci P.,et al.Hum. Genet. 87:642-648(1991).
Krajci P.,et al.Eur. J. Immunol. 22:2309-2315(1992).
Dong X.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Krajci P.,et al.Biochem. Biophys. Res. Commun. 158:783-789(1989).

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$ 467.50
Cat# ALS10980
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