|Dilution||IHC-P (15-20 µg/ml)|
|Other Names||Sushi domain-containing protein 2, SUSD2|
|Target/Specificity||Human SUSD2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||SUSD2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells.|
|Tissue Location||Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
May play a role in breast tumorigenesis.
Dunham I.,et al.Nature 402:489-495(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).
Watson A.P.,et al.Mol. Cancer Res. 11:74-85(2013).
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