SUSD2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q9UGT4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 90kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 56241 |
---|---|
Other Names | Sushi domain-containing protein 2, SUSD2 |
Target/Specificity | Human SUSD2. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | SUSD2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SUSD2 |
---|---|
Function | May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells |
Tissue Location | Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403) |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in breast tumorigenesis.
References
Dunham I.,et al.Nature 402:489-495(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).
Watson A.P.,et al.Mol. Cancer Res. 11:74-85(2013).
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