|Dilution||IHC-P (5 µg/ml)|
|Other Names||Sushi domain-containing protein 2, SUSD2|
|Target/Specificity||Human SUSD2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||SUSD2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells.|
|Tissue Location||Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403)|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in breast tumorigenesis.
Dunham I.,et al.Nature 402:489-495(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).
Watson A.P.,et al.Mol. Cancer Res. 11:74-85(2013).
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