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BACE1 / BACE Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - BACE1 / BACE Antibody (C-Terminus) ALS10993
    Anti-BACE1 antibody ALS10993 IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P56817
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 56kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 23621
Other Names Beta-secretase 1, 3.4.23.46, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149
Target/Specificity Human BACE1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CPD (39%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsBACE1 / BACE Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BACE1
Synonyms BACE, KIAA1149
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Cellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P56818}. Endoplasmic reticulum. Endosome {ECO:0000250|UniProtKB:P56818}. Cell surface. Cytoplasmic vesicle membrane. Membrane raft {ECO:0000250|UniProtKB:P56818} Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface
Tissue Location Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata
Research Areas
Citations (0)

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Background

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

References

Vassar R.,et al.Science 286:735-741(1999).
Sinha S.,et al.Nature 402:537-540(1999).
Yan R.,et al.Nature 402:533-537(1999).
Hussain I.,et al.Mol. Cell. Neurosci. 14:419-427(1999).
Michel B.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS10993
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