|Reactivity||Human, Mouse, Rabbit, Pig, Horse, Bovine|
|Dilution||IHC-P (10-15 µg/ml)|
|Other Names||Proto-oncogene Wnt-1, Proto-oncogene Int-1 homolog, WNT1, INT1|
|Target/Specificity||Human WNT1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||WNT1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
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Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.
van Ooyen A.,et al.EMBO J. 4:2905-2909(1985).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Doubravska L.,et al.Cell. Signal. 23:837-848(2011).
Keupp K.,et al.Am. J. Hum. Genet. 92:565-574(2013).
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