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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   TRPV4 Antibody (N-Terminus)   

TRPV4 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - TRPV4 Antibody (N-Terminus) ALS10997
    Anti-TRPV4 antibody ALS10997 IHC of human trachea.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9HBA0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 98kDa
Dilution IHC-P (2.5-5 µg/ml)
Additional Information
Gene ID 59341
Other Names Transient receptor potential cation channel subfamily V member 4, TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC, TRPV4, VRL2, VROAC
Target/Specificity Human TRPV4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsTRPV4 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPV4
Synonyms VRL2, VROAC
Function Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum Isoform 5: Cell membrane.
Tissue Location Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level)
Volume 50 µl
Research Areas
Citations (0)

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Background

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

References

Liedtke W.B.,et al.Cell 103:525-535(2000).
Strotmann R.,et al.Nat. Cell Biol. 2:695-702(2000).
Suzuki M.,et al.J. Biol. Chem. 278:22664-22668(2003).
Ishibashi K.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Kelsell R.E.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS10997
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