|Reactivity||Human, Monkey, Dog|
|Dilution||IHC-P (2.5-5 µg/ml)|
|Other Names||Bestrophin-2, Vitelliform macular dystrophy 2-like protein 1, BEST2, VMD2L1|
|Target/Specificity||Human BEST2 / Bestrophin-2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except BEST1 (47%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||BEST2 / Bestrophin-2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Mainly confined to the retinal pigment epithelium and colon.|
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Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Stoehr H.,et al.Eur. J. Hum. Genet. 10:281-284(2002).
Tsunenari T.,et al.J. Biol. Chem. 278:41114-41125(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Sun H.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:4008-4013(2002).
Qu Z.,et al.Am. J. Physiol. 294:C1371-C1377(2008).
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