|Reactivity||Human, Monkey, Chicken|
|Dilution||IHC-P (15-20 µg/ml)|
|Other Names||Transmembrane protein 33, Protein DB83, TMEM33, DB83|
|Target/Specificity||Human TMEM33. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||TMEM33 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Melanosome. Nucleus envelope. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Co- localizes with RTN4 at the ER sheets|
|Tissue Location||Prostate cancer and several cancer cell lines (at protein level). Widely expressed. Expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine-sensitive breast cancer cells. Expressed at higher levels in early recurrence breast cancer tissues as compared to non-recurrent breast tumors.|
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Provided below are standard protocols that you may find useful for product applications.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Chi A.,et al.J. Proteome Res. 5:3135-3144(2006).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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