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TMEM33 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P57088 |
| Reactivity | Human, Monkey, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28kDa |
| Dilution | IHC-P (15-20 µg/ml) |
| Gene ID | 55161 |
|---|---|
| Other Names | Transmembrane protein 33, Protein DB83, TMEM33, DB83 |
| Target/Specificity | Human TMEM33. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | TMEM33 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM33 |
|---|---|
| Synonyms | DB83 |
| Function | Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Melanosome. Nucleus envelope. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Co-localizes with RTN4 at the ER sheets. |
| Tissue Location | Prostate cancer and several cancer cell lines (at protein level). Widely expressed. Expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine- sensitive breast cancer cells. Expressed at higher levels in early recurrence breast cancer tissues as compared to non-recurrent breast tumors. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Chi A.,et al.J. Proteome Res. 5:3135-3144(2006).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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