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TMPRSS4 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - TMPRSS4 Antibody (Internal) ALS11017
    Anti-TMPRSS4 antibody ALS11017 IHC of human pancreas.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NRS4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution IHC-P (15-20 µg/ml)
Additional Information
Gene ID 56649
Other Names Transmembrane protease serine 4, 3.4.21.-, Channel-activating protease 2, CAPH2, Membrane-type serine protease 2, MT-SP2, TMPRSS4, TMPRSS3
Target/Specificity Human TMPRSS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsTMPRSS4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMPRSS4 (HGNC:11878)
Function Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity).
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Probable protease. Seems to be capable of activating ENaC (By similarity).

References

Wallrapp C.,et al.Cancer Res. 60:2602-2606(2000).
Smeekens S.S.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 467.50
Cat# ALS11017
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