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GM2A Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P17900 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21kDa |
| Dilution | IHC-P (5-7.5 µg/ml) |
| Gene ID | 2760 |
|---|---|
| Other Names | Ganglioside GM2 activator, Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, Ganglioside GM2 activator isoform short, GM2A |
| Target/Specificity | Human GM2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NBR1 (53%). |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | GM2A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GM2A (HGNC:4367) |
|---|---|
| Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium- independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D- galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (PubMed:17552909). |
| Cellular Location | Lysosome. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
References
Xie B.,et al.Biochem. Biophys. Res. Commun. 177:1217-1223(1991).
Klima H.,et al.FEBS Lett. 289:260-264(1991).
Nagarajan S.,et al.Biochem. J. 282:807-813(1992).
Xie B.,et al.Genomics 14:796-798(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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