|Dilution||IHC-P (10-12.5 µg/ml)|
|Other Names||Ly6/PLAUR domain-containing protein 3, GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, LYPD3, C4.4A|
|Target/Specificity||Human LYPD3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||C4.4A / LYPD3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers|
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Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
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Wuerfel J.,et al.Gene 262:35-41(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Grimwood J.,et al.Nature 428:529-535(2004).
Hansen L.V.,et al.Biochem. Eng. J. 380:845-857(2004).
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