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SLC4A2 / AE2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P04920 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Pig, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 137kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 6522 |
|---|---|
| Other Names | Anion exchange protein 2, AE 2, Anion exchanger 2, Non-erythroid band 3-like protein, BND3L, Solute carrier family 4 member 2, SLC4A2, AE2, EPB3L1, HKB3, MPB3L |
| Target/Specificity | Human SLC4A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | SLC4A2 / AE2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC4A2 |
|---|---|
| Synonyms | AE2, EPB3L1, HKB3, MPB3L |
| Function | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T- cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). |
| Cellular Location | [Isoform A]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein [Isoform B2]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | [Isoform A]: Expressed in the liver, stomach, kidney, prostate, thyroid and rectum. [Isoform B2]: Expressed in the liver and kidney. |
| Volume | 455 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plasma membrane anion exchange protein of wide distribution.
References
Gehrig H.,et al.Biochim. Biophys. Acta 1130:326-328(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Demuth D.R.,et al.EMBO J. 5:1205-1214(1986).
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