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SLC11A2 / DMT1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - SLC11A2 / DMT1 Antibody (Internal) ALS11084
    Anti-SLC11A2 antibody ALS11084 IHC of human, pancreas.
  • IHC - SLC11A2 / DMT1 Antibody (Internal) ALS11084
    Anti-SLC11A2 antibody ALS11084 IHC of human, kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P49281
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 62kDa
Dilution IHC-P (15-20 µg/ml)
Additional Information
Gene ID 4891
Other Names Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2, SLC11A2, DCT1, DMT1, NRAMP2
Target/Specificity Human SLC11A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsSLC11A2 / DMT1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC11A2
Synonyms DCT1, DMT1, NRAMP2
Function Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.
Cellular Location Isoform 2: Cell membrane; Multi- pass membrane protein. Early endosome
Tissue Location Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.
Volume 50 µl
Research Areas
Citations (0)

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Background

Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.

References

Kishi F.,et al.Mol. Immunol. 34:839-842(1997).
Kishi F.,et al.Biochem. Biophys. Res. Commun. 251:775-783(1998).
Lee P.L.,et al.Blood Cells Mol. Dis. 24:199-215(1998).
Hubert N.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12345-12350(2002).
Worthington M.T.,et al.Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11084
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