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> home > Products > Primary Antibodies > Signal Transduction > SLC39A6 / LIV-1 Antibody (N-Terminus)
SLC39A6 / LIV-1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q13433 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 85kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 25800 |
|---|---|
| Other Names | Zinc transporter ZIP6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, Zrt- and Irt-like protein 6, ZIP-6, SLC39A6, LIV1, ZIP6 |
| Target/Specificity | Human SLC39A6. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | SLC39A6 / LIV-1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC39A6 (HGNC:18607) |
|---|---|
| Synonyms | LIV1, ZIP6 |
| Function | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:27274087, PubMed:18272141, PubMed:21422171, PubMed:34394081, PubMed:23919497, PubMed:12839489). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to- mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:30552163, PubMed:21422171, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, lamellipodium membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q4V887} Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (PubMed:34394081) In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q4V887, ECO:0000269|PubMed:34394081} |
| Tissue Location | Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum (PubMed:12839489). Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma (PubMed:12839489). |
| Volume | 50 µl |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
May act as a zinc-influx transporter.
References
Green C.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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$ 467.50
Cat# ALS11086
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