|Reactivity||Human, Horse, Dog|
|Dilution||IHC-P (5-7.5 µg/ml)|
|Other Names||Beta-1, 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase 3, 188.8.131.52, 184.108.40.206, C2GnT-mucin type, C2GnT-M, hC2GnT-M, Core 2/core 4 beta-1, 6-N-acetylglucosaminyltransferase, C2/4GnT, GCNT3|
|Target/Specificity||Human GCNT3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GCNT3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.|
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Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
Yeh J.-C.,et al.J. Biol. Chem. 274:3215-3221(1999).
Schwientek T.,et al.J. Biol. Chem. 274:4504-4512(1999).
Tan S.,et al.Am. J. Respir. Cell Mol. Biol. 36:737-745(2007).
Ishibashi Y.,et al.Glycoconj. J. 22:53-62(2005).
Huang M.-C.,et al.Oncogene 25:3267-3276(2006).
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