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ITGA2 / CD49b Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - ITGA2 / CD49b Antibody (Extracellular Domain) ALS11108
    Anti-ITGA2 / CD49b antibody ALS11108 IHC of human thymus, medulla.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P17301
Reactivity Human, Monkey, Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 129kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3673
Other Names Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B
Target/Specificity Human ITGA2 / CD49b. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsITGA2 / CD49b Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA2
Synonyms CD49B
Function Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

References

Takada Y.,et al.J. Cell Biol. 109:397-407(1989).
Schmutz J.,et al.Nature 431:268-274(2004).
Zutter M.M.,et al.J. Biol. Chem. 269:463-469(1994).
Bergelson J.M.,et al.J. Virol. 67:6847-6852(1993).
Graham K.L.,et al.J. Virol. 77:9969-9978(2003).

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$ 395.00
Cat# ALS11108
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