KATII / AADAT Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
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Primary Accession | Q8N5Z0 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 47kDa |
Dilution | IHC-P (2.5 µg/ml) |
Gene ID | 51166 |
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Other Names | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, 2.6.1.39, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, 2.6.1.7, Kynurenine--oxoglutarate transaminase II, AADAT, KAT2 |
Target/Specificity | Human AADAT. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C. |
Precautions | KATII / AADAT Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AADAT (HGNC:17929) |
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Function | Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). |
Cellular Location | Mitochondrion. |
Tissue Location | Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary |
Volume | 50 µl |
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Background
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
References
Gatti S.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Goh D.L.M.,et al.Mol. Genet. Metab. 76:172-180(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Han Q.,et al.Biosci. Rep. 28:205-215(2008).
Han Q.,et al.J. Biol. Chem. 283:3567-3573(2008).
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