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KATII / AADAT Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - KATII / AADAT Antibody (Internal) ALS11112
    Anti-KATII / AADAT antibody IHC of human Colon, Carcinoma.
    detail
  • IHC - KATII / AADAT Antibody (Internal) ALS11112
    Anti-AADAT antibody ALS11112 IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8N5Z0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 51166
Other Names Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, 2.6.1.39, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, 2.6.1.7, Kynurenine--oxoglutarate transaminase II, AADAT, KAT2
Target/Specificity Human AADAT. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsKATII / AADAT Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AADAT (HGNC:17929)
Function Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
Cellular Location Mitochondrion.
Tissue Location Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary
Research Areas
Citations (0)
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Background

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

References

Gatti S.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Goh D.L.M.,et al.Mol. Genet. Metab. 76:172-180(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Han Q.,et al.Biosci. Rep. 28:205-215(2008).
Han Q.,et al.J. Biol. Chem. 283:3567-3573(2008).

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Discontinued
Cat# ALS11112
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