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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDHR5 / MUCDHL Antibody (Cytoplasmic Domain)   

CDHR5 / MUCDHL Antibody (Cytoplasmic Domain)

Rabbit Polyclonal Antibody

     
  • IHC - CDHR5 / MUCDHL Antibody (Cytoplasmic Domain) ALS11119
    Anti-CDHR5 / MUPCDH antibody ALS11119 IHC of human kidney.
  • IHC - CDHR5 / MUCDHL Antibody (Cytoplasmic Domain) ALS11119
    Anti-CDHR5 / MUPCDH antibody ALS11119 IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9HBB8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 88kDa
Dilution IHC-P (5-7.5 µg/ml)
Additional Information
Gene ID 53841
Other Names Cadherin-related family member 5, Mu-protocadherin, Mucin and cadherin-like protein, CDHR5, MUCDHL, MUPCDH
Target/Specificity Human CDHR5 / MUPCDH. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCDHR5 / MUCDHL Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDHR5 (HGNC:7521)
Function Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
Cellular Location Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein
Tissue Location Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409)
Research Areas
Citations (0)

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Background

Acts as a calcium-dependent cell adhesion protein.

References

Paris M.J.,et al.Genomics 69:196-202(2000).
Soleiman A.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 395.00
Cat# ALS11119
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