ESYT1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
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Primary Accession | Q9BSJ8 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 123kDa |
Dilution | IHC-P (10-12.5 µg/ml) |
Gene ID | 23344 |
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Other Names | Extended synaptotagmin-1, E-Syt1, Membrane-bound C2 domain-containing protein, ESYT1, FAM62A, KIAA0747, MBC2 |
Target/Specificity | Human ESYT1 / FAM62A. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | ESYT1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ESYT1 (HGNC:29534) |
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Synonyms | FAM62A, KIAA0747, MBC2 |
Function | Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes primarily to the endoplasmic reticulum (PubMed:29469807). Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:29469807, PubMed:22250200). |
Tissue Location | Widely expressed.. |
Volume | 50 µl |
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Background
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
References
Min S.-W.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:3823-3828(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 5:277-286(1998).
Bienvenut W.V.,et al.Submitted (NOV-2005) to UniProtKB.
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