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KCNH2 / HERG Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - KCNH2 / HERG Antibody (Internal) ALS11124
    Anti-KCNH2 / Kv11.1 antibody ALS11124 IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q12809
Reactivity Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 127kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 3757
Other Names Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, Voltage-gated potassium channel subunit Kv11.1, KCNH2, ERG, ERG1, HERG
Target/Specificity Human KCNH2 / Kv11.1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsKCNH2 / HERG Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNH2
Synonyms ERG, ERG1, HERG
Function Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells
Research Areas
Citations (0)

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Background

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.

References

Warmke J.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:3438-3442(1994).
Itoh T.,et al.Hum. Genet. 102:435-439(1998).
Soejima H.,et al.Genomics 74:115-120(2001).
Downie D.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Crociani O.,et al.J. Biol. Chem. 278:2947-2955(2003).

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$ 395.00
Cat# ALS11124
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