|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, Voltage-gated potassium channel subunit Kv11.1, KCNH2, ERG, ERG1, HERG|
|Target/Specificity||Human KCNH2 / Kv11.1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||KCNH2 / HERG Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ERG, ERG1, HERG|
|Function||Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells|
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Provided below are standard protocols that you may find useful for product applications.
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
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Itoh T.,et al.Hum. Genet. 102:435-439(1998).
Soejima H.,et al.Genomics 74:115-120(2001).
Downie D.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Crociani O.,et al.J. Biol. Chem. 278:2947-2955(2003).
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