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KCNN2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - KCNN2 Antibody (C-Terminus) ALS11125
    Anti-KCNN2 antibody ALS11125 IHC of human kidney.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9H2S1
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 64kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 3781
Other Names Small conductance calcium-activated potassium channel protein 2, SK2, SKCa 2, SKCa2, KCa2.2, KCNN2
Target/Specificity Human KCNN2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsKCNN2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNN2
Function Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:10991935, PubMed:9287325, PubMed:33242881). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed in atrial myocytes (at protein level). Widely expressed.
Research Areas
Citations (0)
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Background

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

References

Desai R.,et al.J. Biol. Chem. 275:39954-39963(2000).
Xu Y.,et al.J. Biol. Chem. 278:49085-49094(2003).
Mazzone J.N.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).

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Discontinued
Cat# ALS11125
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