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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KCNN4 / KCa3.1 Antibody (N-Terminus)   

KCNN4 / KCa3.1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - KCNN4 / KCa3.1 Antibody (N-Terminus) ALS11126
    Anti-KCNN4 antibody ALS11126 IHC of human pancreas.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O15554
Reactivity Human, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3783
Other Names Intermediate conductance calcium-activated potassium channel protein 4, SK4, SKCa 4, SKCa4, IKCa1, IK1, KCa3.1, KCa4, Putative Gardos channel, KCNN4, IK1, IKCA1, KCA4, SK4
Target/Specificity Human KCNN4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsKCNN4 / KCa3.1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNN4
Synonyms IK1, IKCA1, KCA4, SK4
Function Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Widely expressed in non-excitable tissues.
Research Areas
Citations (0)

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Background

Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

References

Joiner W.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11013-11018(1997).
Ishii T.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11651-11656(1997).
Logsdon N.J.,et al.J. Biol. Chem. 272:32723-32726(1997).
Ghanshani S.,et al.Genomics 51:160-161(1998).
Ghanshani S.,et al.J. Biol. Chem. 275:37137-37149(2000).

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$ 395.00
Cat# ALS11126
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