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P2RX7 / P2X7 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q99572 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 69kDa |
| Dilution | IHC-P (10-20 µg/ml) |
| Gene ID | 5027 |
|---|---|
| Other Names | P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7 |
| Target/Specificity | Human P2RX7 / P2X7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DDX59 (56%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | P2RX7 / P2X7 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RX7 |
|---|---|
| Function | Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed with highest levels in brain and immune tissues. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
References
Rassendren F.,et al.J. Biol. Chem. 272:5482-5486(1997).
Buell G.N.,et al.Recept. Channels 5:347-354(1998).
Cheewatrakoolpong B.,et al.Biochem. Biophys. Res. Commun. 332:17-27(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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