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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   ARTS1 / ERAP1 Antibody (C-Terminus)   

ARTS1 / ERAP1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - ARTS1 / ERAP1 Antibody (C-Terminus) ALS11162
    Anti-ERAP1 / ARTS1 antibody ALS11162 IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NZ08
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 107kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 51752
Other Names Endoplasmic reticulum aminopeptidase 1, 3.4.11.-, ARTS-1, Adipocyte-derived leucine aminopeptidase, A-LAP, Aminopeptidase PILS, Puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, ERAP1, APPILS, ARTS1, KIAA0525
Target/Specificity Human ERAP1 / ARTS1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsARTS1 / ERAP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERAP1
Synonyms APPILS, ARTS1, KIAA0525
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein
Tissue Location Ubiquitous.
Volume 50 µl
Research Areas
Citations (0)

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Background

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

References

Hattori A.,et al.J. Biochem. 125:931-938(1999).
Hattori A.,et al.J. Biochem. 130:235-241(2001).
Schomburg L.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Cui X.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 5:31-39(1998).

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$ 395.00
Cat# ALS11162
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