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AICDA / AID Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | Q9GZX7 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24kDa |
| Dilution | ICC (10 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml) |
| Gene ID | 57379 |
|---|---|
| Other Names | Single-stranded DNA cytosine deaminase, 3.5.4.38, Activation-induced cytidine deaminase, Cytidine aminohydrolase, AICDA, AID |
| Target/Specificity | peptide corresponding to 14 amino acids near the carboxy-terminus of human AID |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | AICDA / AID Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AICDA |
|---|---|
| Synonyms | AID |
| Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). |
| Cellular Location | Nucleus. Cytoplasm, cytosol Note=Predominantly cytosolic (PubMed:21385873). In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity) {ECO:0000250|UniProtKB:Q9WVE0, ECO:0000269|PubMed:21385873} |
| Tissue Location | Strongly expressed in lymph nodes and tonsils. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
References
Muto T.,et al.Genomics 68:85-88(2000).
Revy P.,et al.Cell 102:565-575(2000).
Martin A.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12304-12308(2002).
Roa S.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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