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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   HCRT / Orexin Antibody   

HCRT / Orexin Antibody

Sheep Polyclonal Antibody

     
  • IHC - HCRT / Orexin Antibody ALS11216
    Anti-HCRT / Orexin antibody IHC of human brain, hypothalamus.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, IHC-Fr
Primary Accession O43612
Reactivity Human
Host Sheep
Clonality Polyclonal
Calculated MW 13kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3060
Other Names Orexin, Hypocretin, Hcrt, Orexin-A, Hypocretin-1, Hcrt1, Orexin-B, Hypocretin-2, Hcrt2, HCRT, OX, PPORX, PPOX
Target/Specificity Specific for human orexin A.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsHCRT / Orexin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCRT
Synonyms OX, PPORX, PPOX
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Cellular Location Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Tissue Location Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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Background

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

References

Sakurai T.,et al.Cell 92:573-585(1998).
Sakurai T.,et al.J. Biol. Chem. 274:17771-17776(1999).
Lee J.-H.,et al.Eur. J. Biochem. 266:831-839(1999).
Hungs M.,et al.Bioessays 23:397-408(2001).
Willie J.T.,et al.Annu. Rev. Neurosci. 24:429-458(2001).

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$ 395.00
Cat# ALS11216
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