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MLC2 / MYL9 Antibody (aa12-27)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | P24844 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20kDa |
| Dilution | ELISA (1:5000-1:20000), IHC-P (2.5 µg/ml), WB (1:500-1:2000) |
| Gene ID | 10398 |
|---|---|
| Other Names | Myosin regulatory light polypeptide 9, 20 kDa myosin light chain, LC20, MLC-2C, Myosin RLC, Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9, Myosin regulatory light chain MRLC1, MYL9, MLC2, MRLC1, MYRL2 |
| Target/Specificity | Amino acids 12-27 of human myosin light chain protein. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MLC2 / MYL9 Antibody (aa12-27) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYL9 |
|---|---|
| Synonyms | MLC2, MRLC1, MYRL2 |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9CQ19}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9CQ19}. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts {ECO:0000250|UniProtKB:Q9CQ19} |
| Tissue Location | Smooth muscle tissues and in some, but not all, nonmuscle cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.
References
Kumar C.C.,et al.Biochemistry 28:4027-4035(1989).
Pan J.Y.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Iwasaki T.,et al.Cell Struct. Funct. 26:677-683(2001).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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