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GLI2 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P10070 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 168kDa |
| Dilution | ELISA (1:15000-1:60000), IHC-P (5 µg/ml), WB (1:500-1:2000) |
| Gene ID | 2736 |
|---|---|
| Other Names | Zinc finger protein GLI2, GLI family zinc finger protein 2 {ECO:0000312|HGNC:HGNC:4318}, Tax helper protein, GLI2 (HGNC:4318) |
| Target/Specificity | Amino acids from an internal region of Mouse Gli-2. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GLI2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLI2 (HGNC:4318) |
|---|---|
| Function | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q0VGT2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q0VGT2}. Note=STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus {ECO:0000250|UniProtKB:Q0VGT2} [Isoform 2]: Nucleus |
| Tissue Location | Expressed in breast cancers (at protein level) (PubMed:26565916). Isoform 1 and isoform 4 are expressed in HTLV-1- infected T-cell lines (at protein level) (PubMed:9557682). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines (PubMed:9557682). Isoform 3 and isoform 4 are weakly expressed in HTLV- 1-infected T-cell lines (PubMed:9557682). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. May play a role during embryogenesis.
References
Tanimura A.,et al.J. Virol. 72:3958-3964(1998).
Roessler E.,et al.Hum. Mol. Genet. 14:2181-2188(2005).
Hillier L.W.,et al.Nature 434:724-731(2005).
Tanimura A.,et al.J. Virol. 67:5375-5382(1993).
Ruppert J.M.,et al.Mol. Cell. Biol. 8:3104-3113(1988).
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