|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:3000-1:12000), IHC-P (2.5 µg/ml), WB (1:100-1:1000)|
|Other Names||Protein sprouty homolog 4, Spry-4, SPRY4|
|Target/Specificity||Amino acids 306-322 of Human Sprouty-4 protein.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||Sprouty 4 / SPRY4 Antibody (aa306-322) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.|
|Cellular Location||Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
Leeksma O.C.,et al.Eur. J. Biochem. 269:2546-2556(2002).
Ding W.,et al.Am. J. Physiol. 287:L52-L59(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Sasaki A.,et al.Nat. Cell Biol. 5:427-432(2003).
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