|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:3000-1:12000), IHC-P (2.5 µg/ml), WB (1:100-1:1000)|
|Other Names||Protein sprouty homolog 4, Spry-4, SPRY4|
|Target/Specificity||Amino acids 306-322 of Human Sprouty-4 protein.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||Sprouty 4 / SPRY4 Antibody (aa306-322) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.|
|Cellular Location||Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
Leeksma O.C.,et al.Eur. J. Biochem. 269:2546-2556(2002).
Ding W.,et al.Am. J. Physiol. 287:L52-L59(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Sasaki A.,et al.Nat. Cell Biol. 5:427-432(2003).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.