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Sprouty 4 / SPRY4 Antibody (aa306-322)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9C004 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33kDa |
| Dilution | ELISA (1:3000-1:12000), IHC-P (2.5 µg/ml), WB (1:100-1:1000) |
| Gene ID | 81848 |
|---|---|
| Other Names | Protein sprouty homolog 4, Spry-4, SPRY4 |
| Target/Specificity | Amino acids 306-322 of Human Sprouty-4 protein. |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | Sprouty 4 / SPRY4 Antibody (aa306-322) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPRY4 |
|---|---|
| Function | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). |
| Cellular Location | Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) (By similarity). Colocalizes with TESK1 in vesicular spots in the cytoplasm (PubMed:15584898) {ECO:0000250|UniProtKB:Q9WTP2, ECO:0000269|PubMed:15584898} |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
References
Leeksma O.C.,et al.Eur. J. Biochem. 269:2546-2556(2002).
Ding W.,et al.Am. J. Physiol. 287:L52-L59(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Sasaki A.,et al.Nat. Cell Biol. 5:427-432(2003).
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