|Application ||WB, IHC-P, E, IP|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:5000-1:20000), IHC-P (10 µg/ml), WB (1:1000-1:5000)|
|Other Names||Cyclin-L1, Cyclin-L, CCNL1|
|Target/Specificity||Synthetic construct consisting of full length Human Cyclin L1b protein.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||CCNL1 / Cyclin L1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).|
|Cellular Location||Nucleus speckle. Nucleus, nucleoplasm. Note=Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.|
|Tissue Location||Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC)|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
Dickinson L.A.,et al.J. Biol. Chem. 277:25465-25473(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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