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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CCNL1 / Cyclin L1 Antibody   

CCNL1 / Cyclin L1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - CCNL1 / Cyclin L1 Antibody ALS11242
    Anti-CCNL1 / Cyclin L1 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession Q9UK58
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 60kDa
Dilution ELISA (1:5000-1:20000), IHC-P (10 µg/ml), WB (1:1000-1:5000)
Additional Information
Gene ID 57018
Other Names Cyclin-L1, Cyclin-L, CCNL1
Target/Specificity Synthetic construct consisting of full length Human Cyclin L1b protein.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsCCNL1 / Cyclin L1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNL1
Function Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
Cellular Location Nucleus speckle. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing
Tissue Location Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Research Areas
Citations (0)

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Background

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

References

Dickinson L.A.,et al.J. Biol. Chem. 277:25465-25473(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS11242
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