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OAS3 / p100 Antibody (aa1070-1087)

Rabbit Polyclonal Antibody

     
  • IHC - OAS3 / p100 Antibody (aa1070-1087) ALS11247
    Anti-OAS3 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y6K5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 121kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml), WB (1:100-1:500)
Additional Information
Gene ID 4940
Other Names 2'-5'-oligoadenylate synthase 3, (2-5')oligo(A) synthase 3, 2-5A synthase 3, 2.7.7.84, p100 OAS, p100OAS, OAS3
Target/Specificity Amino acids 1070 to 1087 of human OAS3
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsOAS3 / p100 Antibody (aa1070-1087) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OAS3
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Cellular Location Cytoplasm. Nucleus.
Tissue Location Present at high level in placenta trophoblast.
Research Areas
Citations (0)

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Background

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

References

Rebouillat D.,et al.J. Biol. Chem. 274:1557-1565(1999).
Ito M.,et al.Cancer Res. 61:2038-2046(2001).
Scherer S.E.,et al.Nature 440:346-351(2006).
Rebouillat D.,et al.Genomics 70:232-240(2000).
Bienvenut W.V.,et al.Submitted (JUN-2009) to UniProtKB.

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$ 395.00
Cat# ALS11247
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